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  • C1108 - Anti-Cannabinoid Receptor 1 antibody produced in rabbit

C1108 Sigma

Anti-Cannabinoid Receptor 1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Neurotransmission, Antibodies to Neurotransmitter Receptors, CAM-CB,
species reactivity   rat, human
application(s)   immunocytochemistry: suitable
  western blot: suitable
clone   polyclonal
concentration   1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
mol wt   antigen mol wt ~52 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... CNR1(1268)
rat ... Cnr1(25248)
biological source   rabbit
conjugate   unconjugated



fusion protein containing amino acids 1-99 of the human CB1 receptor.

Physical form

Solution in phosphate buffered saline containing 1 mg/ml bovine serum albumin, 50% glycerol, and 0.05% sodium azide.


Anti-Cannabinoid Receptor 1 antibody produced in rabbit is suitable for western blotting at a working dilution of 1:250 and for immunocytochemistry at a working dilution of 1:1000.

Biochem/physiol Actions

Cannabinoids exert their well-known physiological effects through two G-protein coupled receptors, CB1 and CB2. The cannabinoid receptor type 1 (CB1) is widely distributed in mammalian tissues, with the highest concentrations found in brain neurons while CB2 receptor function primarily in the peripheral immune system, found in spleen and may be present in the central nervous system, including the retina. The cannabinoid receptor type 1 are involved in modulation of adenylate cyclase and ion channels. It is also involved in the modulation of nociception, movement, learning and memory, emotion and many other neuronal processes. It also plays an essential role in drug addiction. CB1 receptor blockade may be useful for treatment of angiotensin II-dependent hypertension and associated metabolic syndrome.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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