Synonym: 3α,7α,12α-Trihydroxy-5β-cholanic acid, Cholanic acid
|Related Categories||Analytical Reagents, Analytical/Chromatography, Anionic Detergents, Antigen-Vaccine Preparation, Application Specific Reagents,|
|biological source||from ox or sheep bile|
|Gene Information||human ... CYP1A2(1544)|
Non-denaturing ionic detergent used for extraction of membrane proteins.
Dietary cholic acid has been used in a study to assess its effect on colonic epithelial cell proliferation. 1 It has also been used in a study to investigate extractions and comparisons of human erythrocyte ghosts. 2
Cholic acid is a major primary bile acid produced in the liver which facilitates fat absorption and cholesterol excretion. It is a non-denaturing ionic detergent.
1 kg in poly bottle
25, 100, 500 g in poly bottle
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1129.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Certificate of Analysis
Certificate of Origin
The liver excretes excess cholesterol in the form of bile acids. Bile acids serve two purposes: to remove unwanted cholesterol from the body and to aid in lipid digestion in the intestine. Bile acids...
BioFiles 2007, 2.7, 17.
Keywords: Absorption, Digestions, Transcription
Assembly Of Nuclear DNA-encoded Subunits Into Mitochondrial Complex IV, And Their Preferential Integration Into Supercomplex Forms In Patient Mitochondria. Lazarou, M., et al. FASEB J. 276, 6701-13, (2009)
Examination Of Campylobacter Jejuni Putative Adhesins Leads To The Identification Of A New Protein, Designated FlpA, Required For Chicken Colonization. Flanagan, R.C., et al. Infect. Immun. 77, 2399-407, (2009)
Deciphering the role of charge, hydration, and hydrophobicity for cytotoxic activities and membrane interactions of bile acid based facial amphiphiles. Singh M, Singh A, Kundu S, et al. Biochim. Biophys. Acta 1828(8), 1926-37, (2013)
Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation. Henkel AS, Gooijert KE, Havinga R, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(2), G221-6, (2013)
Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury. Chen Y, Zhou C, Yu Y, et al. Naunyn Schmiedebergs Arch. Pharmacol. 385(8), 797-806, (2012)
Effects of amphiphilic star-shaped poly(ethylene glycol) polymers with a cholic acid core on human red blood cell aggregation. Janvier F, Zhu JX, Armstrong J, et al. J. Mech. Behav. Biomed. Mater. 18, 100-7, (2013)
Effects of restructured pork containing Himanthalia elongata on adipose tissue lipogenic and lipolytic enzyme expression of normo- and hypercholesterolemic rats. González-Torres L, Churruca I, Schultz Moreira AR, et al. J. Nutrigenet. Nutrigenomics 5(3), 158-67, (2012)
Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype. Abu-Hayyeh S, Papacleovoulou G, Lövgren-Sandblom A, et al. Hepatology 57(2), 716-26, (2013)
Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease. Gabbi C, Bertolotti M, Anzivino C, et al. Dig. Liver Dis. 44(12), 1018-26, (2012)
Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid. Jones RD, Repa JJ, Russell DW, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 303(2), G263-74, (2012)
Towards squalamine mimics: synthesis and antibacterial activities of head-to-tail dimeric sterol-polyamine conjugates. Chen WH, Wennersten C, Moellering RC, et al. Chem. Biodivers. 10(3), 385-93, (2013)
Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Cummings BP, Bettaieb A, Graham JL, et al. Dis. Model Mech. 6(2), 443-56, (2013)
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5. Pellicciari, R., et al J. Med. Chem. 50, 4265-4268, (2007)
Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Christopher A Elkins et al Antimicrob. Agents Chemother. 51, 923-9, (2007)
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Hiroyuki Sato et al J. Med. Chem. 51, 1831-41, (2008)
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)
Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. Roberto Pellicciari et al J. Med. Chem. 52, 7958-61, (2009)
Bile acid toxicity structure-activity relationships: correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A). Ruchika Sharma et al Bioorg. Med. Chem. 18, 6886-95, (2010)
Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines. Dominique Brossard et al Eur. J. Med. Chem. 45, 2912-8, (2010)
Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. Christopher A Elkins et al Antimicrob. Agents Chemother. 54, 1007-15, (2010)
FT-IR 2 (3), 4240:B / FT-IR 1 (2), 1057:C / FT-NMR 1 (3), 594:B / IR-Spectra (3), 1499:G / IR-Spectra (2), 1282:C / NMR-Reference 2 (2), 929:A / RegBook 1 (2), 2867:M / Sax 6, 788 / Sigma FT-IR 1 (1), 1221:D / Structure Index 1, 459:A:6
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