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C1129 Sigma

Cholic acid

from ox or sheep bile, ≥98%

Synonym: 3α,7α,12α-Trihydroxy-5β-cholanic acid, Cholanic acid

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Description

Application

Non-denaturing ionic detergent used for extraction of membrane proteins.

Dietary cholic acid has been used in a study to assess its effect on colonic epithelial cell proliferation. It has also been used in a study to investigate extractions and comparisons of human erythrocyte ghosts.

Biochem/physiol Actions

Bile Acid

General description

Cholic acid is a major primary bile acid produced in the liver which facilitates fat absorption and cholesterol excretion. It is a non-denaturing ionic detergent.

Packaging

1 kg in poly bottle

25, 100, 500 g in poly bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1129.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




HEpaRG 5F Clone

Polymeric Drug Delivery Techniques Guide
Safety & Documentation

Safety Information

WGK Germany 
2
RTECS 
FZ9350000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Bile Acids

The liver excretes excess cholesterol in the form of bile acids. Bile acids serve two purposes: to remove unwanted cholesterol from the body and to aid in lipid digestion in the intestine. Bile acids...
BioFiles 2007, 2.7, 17.
Keywords: Absorption, Digestions, Transcription

Fast and Robust HPLC Separation of Bile Acids and Conjugates with Ascentis Express C18

Introduction Bile acids are increasingly recognized as playing an important signaling role in the control of immune response and energy metabolism. Recently, there has been interest in measuring bile...
Clare Glicksman, Michael Wright, Dave Bell, and Anders Fridström
Reporter US, Volume 33.1
Keywords: Bacterial conjugations, Biochemistry, Chromatography, Clinical, Clinical Chemistry, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Sample preparations, Separation, Solvents, Thin layer chromatography

MSMLS Online Plate Map

MSMLS compounds are conveniently provided at 5μg per well, enough for multiple injections. These are high purity (>95%) compounds supplied in an economical, ready to use format. Compounds are arrange...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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Product #

Description

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614149 Cholic acid-2,2,4,4-d4, 98 atom % D, 98% (CP)
614106 Cholic acid-2,2,3,4,4-d5, 98 atom % D, 98% (CP)
605883 Cholic-24-13C acid, 99 atom % 13C, 98% (CP)
778044 Cholic-24-13C acid, 99 atom % 13C, 98% (CP), S & P tested

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