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  • C1229 - Monoclonal Anti-Caspase 10 antibody produced in rat

C1229 Sigma

Monoclonal Anti-Caspase 10 antibody produced in rat

clone 25C2, purified immunoglobulin, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Caspases,
species reactivity   human
application(s)   microarray: suitable
  western blot: 5-10 μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells
clone   25C2, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2a
mol wt   antigen (full length) mol wt 59 kDa
  antigen (subunit) mol wt 17 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CASP10(843)
biological source   rat
conjugate   unconjugated



recombinant p17 subunit of human caspase-10.

General description

Caspases (Cysteine-requiring Aspartate protease) are a family of proteases that share similarities in amino acid sequences, structure and substrate specificity. Caspase-10 is an enzyme encoded by the CASP10 gene in humans. It is also known as Mch4, FLICE2 and ICE-LAP4 and encodes a “long” prodomain protein product of 59kDa (reported also as 55kDa). Four isoforms of caspase 10 (caspase 10a, 10b, 10c and 10d) have the same prodomain but different mature large and small subdomain. Caspase 10 undergoes a cleavage upon activation, leading to p17 and p12 subunits.


Monoclonal Anti-Caspase 10 antibody produced in rat is suitable for microarray and western blotting at a concentration of 5-10μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells.

Biochem/physiol Actions

Caspase 10 is constitutively expressed in many fetal and adult tissues, with the lowest expression observed in brain, kidney, prostate, testis, and colon. Caspase 10 contains two death effector domains (DEDs) involved in the linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. Caspase 10 is one of the earliest caspases involved in the apoptosis induced cascade and may be responsible for the activation of most of the other caspases including caspase 3, 4, 6, 7 ,8 and 9.

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