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C124 Sigma

β-CFT naphthalenedisulfonate monohydrate

solid

Synonym: (−)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate, WIN 35,428 naphthalenedisulfonate monohydrate

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors, C-CH,
InChI Key   XSJPWVYASBDEJI-YEVYTSHMSA-N
form   solid
optical activity   [α]25/D −62.5°, c = 1.0 in H2O(lit.)
drug control   USDEA Schedule II
color   white
solubility   H2O: soluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

Cocaine analog that inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of 26.1 nM, 31.9 nM, and 127 nM, respectively. [11C]-β-CFT and [18F]-β-CFT are ligands for PET imaging of the dopamine transporter in vivo.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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