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C1254 Sigma

Sodium cholate hydrate

from ox and/or sheep bile, ≥99%

Synonym: 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt




Non-denaturing detergent used for extraction of membrane proteins.

Sodium cholate hydrate has been used in a study to assess the effect of phospholipid formulation and surfactants on the dermal delivery of hydrophilic drugs from elastic liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.

Biochem/physiol Actions

Bile Salt

General description

Sodium cholate hydrate is a bio-surfactant which can be used as a reducing reagent in aqueous solution.


1 kg in poly bottle

25, 100, 500 g in poly bottle

5 kg in poly drum

Price and Availability

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Safety & Documentation

Safety Information

NONH for all modes of transport
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Protocols & Articles


Bile Acids

The liver excretes excess cholesterol in the form of bile acids. Bile acids serve two purposes: to remove unwanted cholesterol from the body and to aid in lipid digestion in the intestine. Bile acids...
BioFiles 2007, 2.7, 17.
Keywords: Absorption, Digestions, Transcription

Bile Salts and Bile Salt Hydrolase

Several Lactobacillus and Bifidobacterium probiotic strains exhibit bile salt hydrolase (BSH) activity and are suspected to play a role in combating the negative effects of bile via detoxification of...
Chloe McClanahan
Biofiles Edition 6.2
Keywords: Detoxification, Probiotics, Thin layer chromatography, Titrations

Nanodisc Technology: A Revolutionary System for Study of Membrane Proteins

Membrane proteins are central to biological signaling pathways, regulating transfer of information and energy across cell membranes. They compose roughly 30% of the human proteome, but due to their k...
Carolyn Crankshaw, Product Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 20
Keywords: Cell disruption, Coagulation, Culture media, Detergents, Immobilization, Immunoprecipitation, Ligands, Nuclear magnetic resonance spectroscopy, Raman spectroscopy, Respiratory, Spectroscopy

Probiotics and Human Health

At the beginning of the 20th century, probiotics were thought to have a beneficial effect to the host by improving the intestinal microbial balance. Through his studies and observations, the Russian ...
Chloe McClanahan
BioFiles Edition 6.2
Keywords: AGE, Absorption, Adhesion, Amplification, Anaerobic, Antimicrobials, Apoptosis, Cancer, Capillary electrophoresis, Carcinogens, Cell culture, Cell proliferation, Chromatography, Coagulation, Detoxification, Diagnostic, Diseases, Enzyme activity, Fermentation, Gas chromatography, Gastrointestinal, Genomics, High performance liquid chromatography, Immunology, Inflammation, Magnetic resonance spectroscopy, Metabolism, Metabolites, Microbiology, Molecular biology, Nucleic acid hybridization, Pharmaceutical, Phosphorylations, Polymerase chain reaction, Polymerase chain reaction - quantitative, Prebiotics, Probiotics, Reductions, Respiratory, Sequencing, Thin layer chromatography, Titrations

Peer-Reviewed Papers


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