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C1288 Sigma

Complement C6 deficient serum human

for complement assays

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Complement Deficient Sera, Complement Proteins,
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... C6(729)

Description

Analysis Note

C6 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.

Physical form

Supplied as a solution in PBS, pH 7.4

Application

Complement C6 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C6 may result in an increased susceptibility to Neisseria meningitidis. Research has identified that a mutation which leads to a 31 bp deletion in exon 10 in the C6 gene results in C6 deficiency. A coagulation defect has also been observed in mice that are C6 deficient.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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