• USA Home
  • C1353 - Anti-Calcium Channel (α1A Subunit) (P/Q-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit

EMAIL THIS PAGE TO A FRIEND
C1353 Sigma

Anti-Calcium Channel (α1A Subunit) (P/Q-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   rat, mouse
application(s)   immunohistochemistry: 1:100
  western blot: 1:200
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
mol wt   antigen (major) mol wt 190 kDa
  antigen (minor) mol wt 210 kDa
storage temp.   −20°C
Gene Information   mouse ... Cacna1a(12286)
rat ... Cacna1a(25398)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 865-881 of the α1A subunit of rat brain voltage-gated calcium channel (VGCC, CNA1) (with additional N-terminal lysine and tyrosine) conjugated to KLH.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Application

Anti-Calcium Channel (α1A Subunit) (P/Q-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 and western blotting at a dilution of 1:200.

Biochem/physiol Actions

The Cav2.1 P/Q voltage-dependent calcium channel is encoded by the CACNA1A gene in humans. It is a pore-forming essential subunit embedded in the plasma membrane. Mutation in this gene causes a number of human neurologic diseases including familial hemiplegic migraine. CACNA1A is associated with both hemiplegic migraine and migraine with aura in patients. Mutation in this gene is the cause of Type 2 episodic ataxia (EA2) the most common subtype among a group of rare hereditary syndromes characterized by recurrent attacks of ataxia.

Price and Availability


Antibody Explorer

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?