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C1354 Sigma

Monoclonal Anti-Caspase 11 antibody produced in rat

clone 17D9, purified from hybridoma cell culture

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Caspases,
species reactivity   mouse
application(s)   immunoblotting: 5-10 μg/mL using mouse EL4 cell extracts.
  immunohistochemistry (frozen sections): suitable
  immunoprecipitation: suitable
clone   17D9, monoclonal
concentration   ~1 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2a
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Casp4(12363)
biological source   rat
conjugate   unconjugated

Description

Immunogen

recombinant p30 subunit of mouse caspase 11.

General description

Caspases are proteases having similar structure, substrate specificity and can be divided into three subfamilies based upon their amino acid sequence homology. Caspase 11 belongs to ICE type family with two protein products of 38 and 43 kD and can induce apoptosis in cultured cells due to overexpression. Monoclonal Anti-Caspase 11 antibody can be used in western blottting. It is also useful in study of protease network involved in development and regulation. Monoclonal Anti-Caspase 11 antibody reacts specifically with mouse caspase 11.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Application

Monoclonal Anti-Caspase 11 antibody can be used in immunohistochemistry and immunoprecipitation. It is also useful in immunoblotting

Price and Availability


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