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C1373 Sigma

Anti-CLIC1 (118-130) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-Chloride intracellular channel protein 1, Anti-G6, Anti-NCC27

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Properties

Related Categories Alphabetical Index, Antibodies, CI-CN, Primary Antibodies
species reactivity   human
application(s)   western blot: 1:500-1:2,000
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt ~27 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CLIC1(1192)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 118-130 of human CLIC1

General description

Chloride intracellular channel protein 1 is a protein encoded by the CLIC1 gene in humans. It is a novel chloride ion channel protein found to localize in cell nucleus and is known to be the first human member of a new class of organellar chloride ion channel proteins. It belongs to chloride intracellular channel (CLIC) family of proteins and is a dual-state protein that can exist both as a soluble form and an integral membrane form acting as an ion channel. CLIC1 is expressed in many human tissues.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

CLIC1 (118-130) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about the Sigma Life Science and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Chloride intracellular Channel 1 (CLIC1) is a metamorphic protein which converts from a soluble cytoplasmic protein into a transmembrane protein. It behaves as an ion channel both in cells as well as in artificial lipid bilayers. CLIC1 is involved in the regulation of cell cycle, cell proliferation, and differentiation. Its expression is associated with clinicopathological factors and a poor prognosis of hepatic tumors. It is also involved in the regulation of tumorigenesis.

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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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