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C1399 Sigma

Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse

clone KS-B17.2, ascites fluid

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cytokeratins,
species reactivity   human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
  indirect immunofluorescence: 1:100 using formalin-fixed, paraffin-embedded sections of human tissue
  microarray: suitable
clone   KS-B17.2, monoclonal
antibody form   ascites fluid
isotype   IgG1
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... KRT18(3875)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

keratin from the bovine mammary gland epithelial cell line BMGE.

Specificity

The antibody reacts with a wide variety of simple epithelia (gastrointestinal, respiratory, urinary, liver, and glandular) but does not react with most stratified squamous epithelium (esophagus, epidermis) or non-epithelial cells.

Application

Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse is suitable for the following applications:
• immunohistochemistry (using formalin-fixed, paraffin-embedded sections)
• indirect immunofluorescence: at a working dilution of 1:100 using formalin-fixed, paraffin-embedded sections of human tissue
• microarray

Biochem/physiol Actions

Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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