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C1413 Sigma

Complement C7 deficient serum human

for complement assays

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Complement Deficient Sera, Complement Proteins,
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... C7(730)

Description

Analysis Note

C7 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.

Physical form

Supplied as a solution in PBS, pH 7.4

Application

Complement C7 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). C7 deficiencies in patients with meningococcal meningitis have shown a mutation which results in an 11 bp deletion in exon 6 resulting in a premature stop codon. Additionally, research has suggested that screening of patients with systemic neisserial infection by CH50 or the APH-50 assay can reveal a C7 deficiency.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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