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C1478 Sigma

Anti-Calcium Channel (α1B Subunit) (N-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   rat, mouse
application(s)   immunocytochemistry: suitable using rat brain sections
  immunoprecipitation: suitable
  western blot: 1:100-1:200 using rat brain membranes
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
mol wt   antigen mol wt 210 kDa (low)
  antigen mol wt 240 kDa (high)
storage temp.   −20°C
Gene Information   mouse ... Cacna1b(12287)
rat ... Cacna1b(257648)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 851-867 of the α1B subunit of rat brain voltage-gated calcium channel (VGCC, CNB1), with additional N-terminal lysine and tyrosine, conjugated to KLH.1

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Application

Anti-Calcium Channel (α1B Subunit) (N-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for the following applications:
• immunocytochemistry using rat brain sections
• immunoprecipitation
• western blotting at a dilution of 1:100-1:200 using rat brain membranes

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)

Biochem/physiol Actions

The calcium channel, voltage-dependent, N type, α1B subunit (CACNA1B) or Cav2.2 is encoded by the CACNA1B gene in humans and belongs to the family of voltage-gated calcium channels. It serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events. CACNA1B is expressed primarily in the neurons, have various roles in neuronal functions and are especially involved with neurotransmitter release at the sympathetic nerve terminals. It is localize to presynaptic nerve terminals of nociceptors where they control neurotransmitter release. Ca(v)β subunit relative to the α(1)2.2 subunit is critical, and the points of contact between these subunits are required for Ca(v)β to regulate channel activity. CACNA1B regulate the trafficking and biophysical properties of various channels.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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