Synonym: Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate
|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,|
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Cyclopolypeptide antibiotic. Endotoxin-binding capacity3 Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect 4.
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients 1 and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients 2.
Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin’s lymphoma. Meredith EJ, Holder MJ, Proc. Natl. Acad. Sci. U. S. A. 103, 13485-13490, (2006)
The effect of sinus surgery with intensive follow-up on pathogenic sinus bacteria in patients with cystic fibrosis. Aanaes K, von Buchwald C, Hjuler T, et al. Am. J. Rhinol. Allergy 27(1), e1-4, (2013)
Combined intravenous and intraventricular administration of colistin methanesulfonate in critically ill patients with central nervous system infection. Ziaka M, Markantonis SL, Fousteri M, et al. Antimicrob. Agents Chemother. 57(4), 1938-40, (2013)
Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: a randomised study. Schuster A, Haliburn C, Döring G, et al. Thorax 68(4), 344-50, (2013)
Colistin pharmacokinetics in intensive care unit patients on continuous venovenous haemodiafiltration: an observational study. Markou N, Fousteri M, Markantonis SL, et al. J. Antimicrob. Chemother. 67(10), 2459-62, (2012)
Pharmacokinetics of colistin in cerebrospinal fluid after intraventricular administration of colistin methanesulfonate. Imberti R, Cusato M, Accetta G, et al. Antimicrob. Agents Chemother. 56(8), 4416-21, (2012)
High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study. Dalfino L, Puntillo F, Mosca A, et al. Clin. Infect. Dis. 54(12), 1720-6, (2012)
Efficacies of colistin and tigecycline in mice with experimental pneumonia due to NDM-1-producing strains of Klebsiella pneumoniae and Escherichia coli. Docobo-Pérez F, Nordmann P, Domínguez-Herrera J, et al. Int. J. Antimicrob. Agents 39(3), 251-4, (2012)
Outcome of ventilator-associated pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa treated with aerosolized colistin in neonates: a retrospective chart review. Celik IH, Oguz SS, Demirel G, et al. Eur. J. Pediatr. 171(2), 311-6, (2012)
Pharmacokinetics of colistin and colistimethate sodium after a single 80-mg intravenous dose of CMS in young healthy volunteers. Couet W, Grégoire N, Gobin P, et al. Clin. Pharmacol. Ther. 89(6), 875-9, (2011)
Colistin methanesulfonate and colistin pharmacokinetics in critically ill patients receiving continuous venovenous hemodiafiltration. Karvanen M, Plachouras D, Friberg LE, et al. Antimicrob. Agents Chemother. 57(1), 668-71, (2013)
Computational fluid dynamics (CFD) assisted performance evaluation of the Twincer™ disposable high-dose dry powder inhaler. de Boer AH, Hagedoorn P, Woolhouse R, et al. J. Pharm. Pharmacol. 64(9), 1316-25, (2012)
Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients. Athanassa ZE, Markantonis SL, Fousteri MZ, et al. Intensive Care Med. 38(11), 1779-86, (2012)
A network meta-analysis of the efficacy of inhaled antibiotics for chronic Pseudomonas infections in cystic fibrosis. Littlewood KJ, Higashi K, Jansen JP, et al. J. Cyst. Fibros. 11(5), 419-26, (2012)
Comparative evaluation of intratracheal colistimethate sodium, imipenem, and meropenem in BALB/c mice with carbapenem-resistant Acinetobacter baumannii pneumonia. Tang HJ, Chuang YC, Ko WC, et al. Int. J. Infect. Dis. 16(1), e34-40, (2012)
Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients. Garonzik SM, Li J, Thamlikitkul V, et al. Antimicrob. Agents Chemother. 55(7), 3284-94, (2011)
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