Colistin sodium methanesulfonate
~11,500 U/mg
DOWNLOAD MSDS (PDF)Synonym: Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate
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CAS Number 8068-28-8
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Empirical Formula (Hill Notation) C58H115N16Na5O28S5
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Molecular Weight 1759.90
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EC Number 232-516-9
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MDL number MFCD00130824
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PubChem Substance ID 24892418
Properties
| Related Categories | A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Cyclopolypeptide antibiotic. Endotoxin-binding capacity3 Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect 4.
Application
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients 1 and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients 2.
Protocols & Applications
Price and Availability
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≥15,000 U/mg
for microbiology
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