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C1608 Sigma

Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse

clone C-1, ascites fluid, buffered aqueous solution

Synonym: Anti-CRABP 1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling, CE-CH,
species reactivity   chicken, monkey, bovine, human, feline, rat, rabbit, turtle
does not react with   frog, (chameleon), goldfish
application(s)   indirect ELISA: suitable
  western blot: suitable
clone   C-1, monoclonal
antibody form   ascites fluid
form   buffered aqueous solution
mol wt   antigen mol wt 16 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... CRABP1(1381)
rat ... Crabp1(25061)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

performic acid oxidized CRABP 1, purified from bovine retina.

General description

Cellular retinoic acid-binding protein 1 is a protein encoded by the CRABP1 gene in humans. It encodes a specific binding protein for a vitamin A family member. It is also referred as RBP5, CRABP, CRABPI and CRABP-I.

Physical form

Solution in phosphate buffered saline containing 0.05% sodium azide.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse is suitable for the following applications:
• indirect ELISA
• western blotting at a dilution of 1:1000
• immunofluorescence at a working dilution of 1:250

Biochem/physiol Actions

Cellular retinoic acid-binding protein 1 (CRABP1) is a prognostic marker for adenocarcinoma and clear cell carcinoma that exhibits chemo-resistance. It is a is a modulator of retinoic acid and plays an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 also functions as a tumor-suppressor in esophageal epithelium and its epigenetic silencing may play a pivotal role during esophageal carcinogenesis.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  nwg
Protocols & Articles

Articles

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

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Peer-Reviewed Papers
15

References

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