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C1688 Sigma

Monoclonal Anti-C-Reactive Protein antibody produced in mouse

clone CRP-8, ascites fluid

Synonym: Anti-CRP

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Immune Cell Signaling and Blood, Antibodies to Human Plasma Proteins,
species reactivity   human
application(s)   dot blot: suitable
  indirect ELISA: 1:40,000
  western blot: 1:200
clone   CRP-8, monoclonal
antibody form   ascites fluid
isotype   IgG1
mol wt   antigen mol wt 24 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CRP(1401)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human C-reactive protein.

Specificity

The antibody recognizes an epitope located on the 24 kDa subunit of denatured and reduced CRP. It does not cross-react with human serum amyloid P component (SAP), human haptoglobin, human α1-acid glycoprotein, human IgG, and CRP from Limulus.

Application

Monoclonal Anti-C-Reactive Protein antibody produced in mouse is suitable for the following:
• dot blot analysis
• indirect ELISA at a working dilution of 1:40,000
• western blotting at a working dilution of 1:200

Biochem/physiol Actions

C-reactive protein (CRP) is a member of the pentraxin family of proteins and synthesized by the liver. It is also known as PTX1. CRP have important host defence, scavenging and metabolic functions. It acts by binding to calcium-dependent exogenous and autologous molecules containing phosphocholine (PC) and activates the complement pathway. It may have pathogenic effects and is a practical prognostic marker in patients with hepatocellular carcinoma (HCC). CRP can be used for upper and lower urinary tract infection differentiation and is considered best for predicting the risk of cardiovascular disease.

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