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C1832 Sigma

Cyclosporin A

from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%

Synonym: Antibiotic S 7481F1, Cyclosporine

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
Quality Level   PREMIUM
biological source   from Tolypocladium inflatum
grade   for molecular biology
InChI Key   PMATZTZNYRCHOR-CGLBZJNRSA-N
product line   BioReagent
assay   ≥95%
form   powder
solubility   dichloromethane: soluble9.80-10.20 mg/mL, clear, colorless to faintly yellow
Mode of action   enzyme | inhibits
storage temp.   2-8°C

Description

Biochem/physiol Actions

Cyclosporin A has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+ - and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. It was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Packaging

5, 10 mg in glass bottle

Application

Cyclosporin A was suitable for:

• Using in in vivo Neovascularization Assay, to subcutaneously inject the mice daily for suppressing the immune response.
• Measuring the multiple drug resistance transporter activity in putative cancer stem/progenitor cells.
• mRNA transcription studies
• analytical standard

General description

Cyclosporin A is a fungal metabolite with immunosuppressive properties. Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.

Price and Availability


Amplified Detection

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GZ4120000
Protocols & Articles

Articles

Cyclosporin A from Tolypocladium inflatum

Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.2 It has been shown to inhibi...
Keywords: Addition reactions, Adsorption, Antibiotics, Cell culture, Centrifugation, Enzyme activity, Enzyme-linked immunosorbent assay, Solvents, Transcription

Peer-Reviewed Papers
15

References

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