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C1860 Sigma

Monoclonal Anti-Clathrin Heavy Chain antibody produced in mouse

clone TD.1, purified from hybridoma cell culture

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell Membrane, Antibodies to Cell and Organelle Proteins,
species reactivity   human, bovine, rat, mouse
application(s)   immunocytochemistry: suitable
  immunoprecipitation: suitable
  microarray: suitable
  western blot: 2-4 μg/mL using whole extract of cultured rat adrenal pheochromocytoma PC-12 cells.
clone   TD.1, monoclonal
concentration   ~2 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
mol wt   antigen mol wt 180-192 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CLTC(1213)
mouse ... Cltc(67300)
rat ... Cltc(54241)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

globular N-terminal domain of bovine clathrin heavy chain.

General description

Clathrin, a three legged structure refer as triskelion is the main component of polygonal network and forms the coat of coated vesicles and coated pits. Clathrin-coated vesicles accounts for receptor mediated endocytosis at the plasma membrane and also play a crucial role in hormone secretion and mechanism of action. Monoclonal Anti-Clathrin Heavy Chain antibody can be used to study the mechanism of clathrin mediated membrane trafficking during hormonal stimulation and protein phosphorylation. Mouse monoclonal anti-clathrin heavy chain antibodies are react specifically with clathrin heavy chain CHC17 but do not cross react with muscle isoform CHC22.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Monoclonal Anti-Clathrin Heavy Chain antibody can be used in immunoblotting. It can also be used in western blotting to characterize clathrin heavy chain levels

Price and Availability


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