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C1897 Sigma

Catechol-O-methyl Transferase from porcine liver

lyophilized powder, ≥150 units/mg protein

Synonym: COMT, Pyrocatechol-O-methyl Transferase, S-Adenosyl-L-methionine:catechol O-methyltransferase

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Description

Biochem/physiol Actions

Major degradative enzyme for catecholamine neurotransmitters; methylates the o-hydroxyl group

Unit Definition

One unit will produce 1.0 nanomole of total O-methylated products from 3,4 dihydroxyacetophenone per hour at pH 7.6 at 37 °C.
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).

Physical form

Lyophilized powder containing phosphate buffer and dithiothreitol

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

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Peer-Reviewed Papers
15

References

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