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C2211 Sigma

Z-Leu-Leu-Leu-al

≥90% (HPLC)

Synonym: MG-132

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Description

Amino Acid Sequence

Z-Leu-Leu-Leu-al

Frequently Asked Questions

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Packaging

5 mg in glass bottle

Biochem/physiol Actions

Potent, membrane-permeable proteasome inhibitor. Induces neurite outgrowth in PC12 cells at 10 μM. Blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types: however, it also activates JNK-1, which initiates apoptosis in response to cell stress.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

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