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C2230 Sigma

Coelenterazine, native

solid

Synonym: 3,2-Dihydro-2-(p-hydroxybenzyl)-6-(p-hydroxyphenyl)-8-benzylimidazolo[1,2-a]pyrazin-3-one, CLZN

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Properties

Related Categories Biochemicals and Reagents, Calcium Probes, Calcium Signaling Research Tools, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   YHIPILPTUVMWQT-UHFFFAOYSA-N
form   solid
color   yellow
solubility   methanol and ethanol: soluble
storage temp.   −20°C

Description

Caution

Protect from exposure to light

Application

Coelenterazine, native was used:-
• For Aequorin assays
• For measuring the intracellular calcium concentration in response to ionomycin or PMA using aequorin in COS-7 cells
• In Bioluminescence imaging for analysing the presence of virus-dependent luciferase activity

Biochem/physiol Actions

Luminophore of the aequorin complex which is oxidized by oxygen to illuminate at 465 nm when Ca2+ binds to the complex; used to measure Ca2+ concentration in cells with high sensitivity and large dynamic range.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

ABC Transporters and Cancer Drug Resistance

Chemotherapy is the treatment of choice against many types of cancer. However, over time chemotherapeutic drugs can become less effective due to the development of resistance that involves a group of...
BioFiles 2007, 2.4, 7.
Keywords: Absorption, Cancer, Clinical, Cloning, Combinatorial synthesis, Diseases, Enzymology, Gene expression, Genetic, Immunology, Pharmaceutical, Reductions, Search, Transfection, Vectors

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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