|drug control||USDEA Schedule IV; Home Office Schedule 4.1; psychotrope; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada|
Anxiolytic; ligand for the GABAA receptor benzodiazepine modulatory site.
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application for HPLC
Certificate of Analysis
|Personal Protective Equipment||Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||63-22-62-68|
|Safety Statements (Europe)||22-36/37|
The phenomenon of "one-trial tolerance" to the anxiolytic effect of chlordiazepoxide in the elevated plus-maze is abolished by the introduction of a motivational conflict situation. Pereira, J.K., et al. Life Sci. 65, PL101, (1999)
Desensitization of a γ-aminobutyric acid type A receptor in rat is increased by chronic treatment with chlordiazepoxide: a molecular mechanism of dependence. Cash, D.J., et al. J. Pharmacol. Exp. Ther. 283, 704, (1997)
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