|Related Categories||A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,|
100, 250 mg in glass bottle
Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.
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|Hazard statements||H302 + H312 + H332-H317-H334-H340-H360|
|Precautionary statements||P201-P261-P280-P308 + P313|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||46-61-20/21/22-42/43|
|Safety Statements (Europe)||53-22-26-36/37/39-45|
Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
BioFiles 2007, 2.4, 20.
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Environmental, Gene expression, Metabolites, Methylations, Mutagens, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription
Increased DNA-binding activity of carboplatin in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Natarajan, G., et al. Biochem. Pharmacol. 58, 1625-1629, (1999)
Structure Index 1, 491:D:2
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