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C261 Sigma

Cytokine Responsive Gene-2 from mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

Synonym: CRG-2/1P-10

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokine Responsive Gene, Cytokines and Growth Factors,
recombinant   expressed in E. coli
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   mouse ... Cxcl10(15945)

Description

Analysis Note

The biological activity is measured by its ability to chemoattract human lymphocytes cultured in the presence of IL-2 for 8-10 days.

Physical form

Lyophilized from 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.

Biochem/physiol Actions

The gene for CRG-2 (mouse homologue of human IP-10), identified as an immediate early gene induced in response to macrophage activation, is reported to be an inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects. CRG-2 mRNA is induced by α/β/γ-interferons and by lipopolysaccharide in macrophages, astrocytes and microglia. CRG-2 shares approximately 67% sequence identity with human IP-10.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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