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C2622 Sigma

Anti-CPSF1 (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-CPSF160, Anti-Cleavage and polyadenylation specific factor 1, 160kDa, Anti-HSU37012, Anti-P/cl.18

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for RNA Regulation and Translation, Antibodies to Ribosomal Proteins and Translation Factors, CO-CP,
species reactivity   human
application(s)   immunoprecipitation: 5-10 μg using lysate of HEK-293T cells over expressing human CPSF1
clone   polyclonal
concentration   ~1.5 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~160 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CPSF1(29894)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 48-63 of human CPSF1, conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-CPSF1 (N-terminal) antibody produced in rabbit is suitable for immunoprecipitation at a working amount of 5-10μg using lysate of HEK-293T cells over expressing human CPSF1.

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Biochem/physiol Actions

Cleavage and polyadenylation specificity factor subunit 1 is a protein encoded by the CPSF1 gene in humans. CPSF1 is the largest subunit of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1 and is located in the nucleus. CPSF is a multi-subunit protein that plays a central role in 3′ processing of mammalian pre-mRNAs. CPF interacts directly with the AAUAAA recognition signal in the RNA and is required for the cleavage as well as for polyadenylation reaction during 3′ processing of messenger RNA precursors.

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Safety Information

WGK Germany  1
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Peer-Reviewed Papers
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C2497 Anti-CPSF1 (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

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