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C2631 Sigma

Concanavalin A from Canavalia ensiformis (Jack bean)

Type III, lyophilized powder

Synonym: Con A

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Properties

type   Type III
form   lyophilized powder
potency   <500 μg per mL agglutination activity
composition   Protein, 10-20% biuret
impurities   Carbohydrate, essentially free
storage temp.   2-8°C

Description

Analysis Note

Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.

Biochem/physiol Actions

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Packaging

Package size based on protein content

Preparation Note

Purified by affinity chromatography.

Physical form

Lyophilized powder containing NaCl

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GK6890000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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C2010 Concanavalin A from Canavalia ensiformis (Jack bean), Type IV, lyophilized powder

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