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C2787 Sigma

Complement C7 from human serum

≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Complement, Complement Factor Proteins,
assay   ≥85% (SDS-PAGE)
concentration   1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2
shipped in   dry ice
storage temp.   −70°C

Description

Quality

Functionally active by a sensitive hemolytic assay.

Biochem/physiol Actions

The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.

A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.

Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.

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Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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