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C2851 Sigma

Anti-CaM Kinase IV (CaMKIV) (AY-18) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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Properties

Related Categories AA - CA, Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human, rat, mouse
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10,000 using sections of rat cerebellum
  microarray: suitable
  western blot: 1:20,000-1:1,000 using rat brain extract and Jurkat, whole cell extract, respectively
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 65 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... CAMK4(814)
mouse ... Camk4(12326)
rat ... Camk4(25050)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

Peptide corresponding to amino acids 457-474 of rat CaM kinase IV conjugated to KLH. This sequence has extensive homology to mouse (80%) and human (70%) CaMKIV.

General description

CaM Kinase IV is a Ca2+/calmodulin-dependent kinase that belongs to serine/threonine protein kinases family. CaM Kinase IV is expressed in the brain and thymus and is localized in cellular cytoplasm and nucleus. It facilitates the phosphorylation of several substrates in brain like-synapsin I, microtubule associated protein (MAP2), tau and tyrosine hydroxylase. Anti-caM kinase IV (CaMKIV) (AY-18) antibody can be used in western blotting (diluted 1:1000 and 1: 20,000) using human T-cell leukemia Jurkat whole cell extract and rat brain extract. It can also be used in microarray. Rabbit anti-caM kinase IV (CaMKIV) (AY-18) antibody reacts specifically with CaMKIV of rat but cross reacts with human CaMKIV.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-caM kinase IV (CaMKIV) (AY-18) antibody (diluted 1:500) can be used as a primary antibody in immunohistochemical studies. It can also be used in immunoblotting to detect and localize CAMKIV (65 kDa).

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WGK Germany  2
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