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C2854 Sigma

Caspase 2 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, >1000 units/mg protein

Synonym: Ich-1, Nedd2

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Properties

Related Categories Apoptosis Enzymes, Apoptosis and Cell Cycle, Application Index, Biochemicals and Reagents, Caspase 1 Substrates,
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   buffered aqueous solution
mol wt   inactive proenzyme mol wt 56 kDa (active form consists of 17 kDa and 10 kDa subunits)
  mol wt ≥30 kDa
Gene Information   human ... CASP2(835)

Description

Unit Definition

One unit will hydrolyze one nmol of N-Acetyl-Val-Asp-Val-Ala-Asp-AFC per min at pH 7.5 at 25 °C.

Physical form

Solution in 25 mM HEPES, pH 7.5, 0.15 M NaCl, 5 mM dithiothreitol, 10% sucrose, with 0.5 mg bovine serum albumin

Biochem/physiol Actions

Caspase 2 plays a major role in both positive and negative regulation of programmed cell death. It exists as two spliced variants, Ich-1L (long) and Ich-1S (short). Functionally, the two forms differ in that overexpression of the long form will induce apoptosis, while overexpression of the short form suppresses cell death.

Price and Availability


Flow Cytometry Instruments
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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