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C2854 Sigma

Caspase 2 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, >1000 units/mg protein

Synonym: Ich-1, Nedd2

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Properties

Related Categories Apoptosis Enzymes, Apoptosis and Cell Cycle, Application Index, Biochemicals and Reagents, Caspase 1 Substrates,
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   buffered aqueous solution
mol wt   inactive proenzyme mol wt 56 kDa (active form consists of 17 kDa and 10 kDa subunits)
  mol wt ≥30 kDa
Gene Information   human ... CASP2(835)

Description

Unit Definition

One unit will hydrolyze one nmol of N-Acetyl-Val-Asp-Val-Ala-Asp-AFC per min at pH 7.5 at 25 °C.

Physical form

Solution in 25 mM HEPES, pH 7.5, 0.15 M NaCl, 5 mM dithiothreitol, 10% sucrose, with 0.5 mg bovine serum albumin

Biochem/physiol Actions

Caspase 2 plays a major role in both positive and negative regulation of programmed cell death. It exists as two spliced variants, Ich-1L (long) and Ich-1S (short). Functionally, the two forms differ in that overexpression of the long form will induce apoptosis, while overexpression of the short form suppresses cell death.

Price and Availability


Flow Cytometry Instruments

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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