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C2917 Sigma

Corticotropin Releasing Factor Antagonist

≥97% (HPLC)

Synonym: α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)

  • CAS Number 99658-03-4

  • Empirical Formula (Hill Notation) C166H274N46O53S2

  • Molecular Weight 3826.36

  •  MDL number MFCD00081543

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Properties

Related Categories CRF, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,
assay   ≥97% (HPLC)
storage temp.   −20°C
Gene Information   human ... CRH(1392)
mouse ... CRH(12918)
rat ... CRH(81648)

Description

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Ala-Glu-Gln-Ala-Leu-Asn-Arg-Leu-Leu-Glu-Ala-NH2

Other Notes

Lyophilized from 0.1% TFA in H2O

Biochem/physiol Actions

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF receptors over human CRF receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

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Amplified Detection

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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