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C2920 Sigma

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

≥98% (TLC), powder

Synonym: FCCP, Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   BMZRVOVNUMQTIN-UHFFFAOYSA-N
Quality Level   PREMIUM
assay   ≥98% (TLC)
form   powder
color   yellow
mp   174-175 °C (dec.)(lit.)
solubility   95% ethanol: soluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

FCCP is a protonophore (H+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. It is capable of depolarizing plasma and mitochondrial membranes. FCCP has been shown to have a number of effects on cellular calcium. It also is reported to inhibit a background K+ current and induce a small inward current, reduce pH by 0.1 unit, and induce a rise of intracellular [Na+]. FCCP stimulates Mg2+-ATPase activity, inhibits β-amyloid production, and mimics the effect of selective glutamate agonist N-methyl-D-aspartate (NMDA) on mitochondrial superoxide production.

Packaging

10 mg in poly bottle

50 mg in glass bottle

Price and Availability


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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
FG5775000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Peer-Reviewed Papers
15

References

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