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C2979 Sigma

Caspase 7 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, ≥1,500 units/mg protein

Synonym: CMH-1, ICE-LAP3, Mch-3

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Description

Analysis Note

Migrates as two major polypeptides (20 kDa and 10 kDa) in immunoblotting. Two minor polypeptides derived from the large subunit are also present.

Unit Definition

One unit will hydrolyze 1.0 nmol of Ac-Asp-Glu-Val-Asp-AFC per minute at pH 7.5 at 25 °C.

Physical form

Solution in HEPES, NaCl, DTT and sucrose, with BSA as a carrier protein

Biochem/physiol Actions

Member of the CED-3 subfamily, the effector caspases, with an essential role in the apoptotic process. Upon activation, the zymogen is translocated to the mitochondrial and microsomal fractions. It is responsible for the cleavage of cellular substrates that precipitate the morphological changes of apoptosis.

Price and Availability


Flow Cytometry Instruments
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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