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C3131 Sigma

Cytochrome c from bovine heart

≥95% based on Mol. Wt. 12,327 basis

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Description

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Packaging

1 g in poly bottle

10, 50, 100, 250 mg in poly bottle

Preparation Note

Prepared with acetic acid without using TCA.

Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Biochem/physiol Actions

The ready interconversion of cytochrome c between ferrous and ferric states makes it an efficient biological electron carrier. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal link in the respiratory chain, it forms the essential electron-bridge between the respirable substrates and oxygen.

Price and Availability


Detect Your Unseen Protein

Flow Cytometry Instruments

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
HA5365000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Protocols

Enzymatic Assay of Ferredoxin NADP Reductase (EC 1.18.12)

To standardize a procedure for the enzymatic assay of Ferredoxin NADP Reductase (EC.1.18.12).
Keywords: Chromatography, Enzymology, Extinction coefficient

Peer-Reviewed Papers
15

References

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