Cathepsin D from bovine spleen
lyophilized powder, ≥5.0 units/mg protein
DOWNLOAD MSDS (PDF)-
CAS Number 9025-26-7
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MDL number MFCD00130749
| Properties
| Related Categories | 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Apoptosis and Cell Cycle, Application Index, Biochemicals and Reagents, |
| form | lyophilized powder |
| mol wt | mol wt ~45 kDa |
| storage temp. | −20°C |
| Gene Information | cow ... CTSD(282883) |
Description
Unit Definition
One unit will produce an increase in A280 of 1.0 per min per mL at pH 3.0 at 37 °C measured as TCA-soluble products using hemoglobin as substrate (1 cm light path).
Physical form
Lyophilized powder containing citrate buffer salts
Biochem/physiol Actions
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Price and Availability
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