|Related Categories||3.4.x.x Peptidases, 3.x.x.x Hydrolases, Apoptosis and Cell Cycle, Application Index, Biochemicals and Reagents,|
|mol wt||mol wt ~45 kDa|
|Gene Information||cow ... CTSD(282883)|
One unit will produce an increase in A280 of 1.0 per min per mL at pH 3.0 at 37 °C measured as TCA-soluble products using hemoglobin as substrate (1 cm light path).
Lyophilized powder containing citrate buffer salts
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
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lyophilized powder, ≥10 units/mg protein
sufficient for 120 assays (100 μL)
lyophilized powder, ≥250 units/mg protein (E
Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Roberg, K., et al. Free Radic. Biol. Med. 27, 1228-1237, (1999)
An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins. Ohsawa, Y., et al. Arch. Histol. Cytol. 61, 395-403, (1998)
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