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C3160 Sigma

Complement C5 from human serum

≥90% (SDS-PAGE), >100,000 C5H50 units/mg protein

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Complement, Complement Factor Proteins,
assay   ≥90% (SDS-PAGE)
concentration   1 mg/mL in PBS, pH 7.2
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... C5(727)

Description

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Quality

Functionally active by a sensitive hemolytic assay.

Application

Complement C5 is part of the terminal sequence in the complement pathway. In particular, it is cleaved into C5a and C5b which are responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis.

Biochem/physiol Actions

Complement component C5 is processed by convertase enzymes in a cascade modulated in a unique way. The multi-subunit catalytic complex initially shows little activity against C5, but instead cleaves C3. A C3 cleavage product C3b covalently attaches to the complex and shifts its specificity to C5 by a factor of 1000.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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