Synonym: AChE, Acetylcholine acetylhydrolase, Cholinesterase, Acetyl
|Related Categories||3.1.x.x Acting on esters, 3.x.x.x Hydrolases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates,|
|composition||Protein, ≥60% biuret|
The activity obtained using acetylcholine as substrate is 30-100 times that obtained with butyrylcholine, using acetylcholinesterase from electric eel.
Major degradative enzyme for acetylcholine in vivo. Converts acetylcholine + H2O to choline + acetic acid.
One unit will hydrolyze 1.0 μmole of acetylcholine to choline and acetate per min at pH 8.0 at 37 °C.
Lyophilized powder containing Tris buffer salts
Molecular Weight: 280 kDa
Isoelectric Point: 5.5
Extinction Coefficient: E1% = 18.0 (280 nm)
Acetylcholinesterase from Electrophorus electricus is a tetramer composed of 4 equal subunits of 70 kDa each. Each subunit contains one active site. The enzyme is a glycoprotein containing hexosamines.
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Certificate of Analysis
Certificate of Origin
Electrochemical biosensing of methyl parathion pesticide based on acetylcholinesterase immobilized onto Au-polypyrrole interlaced network-like nanocomposite. Gong, J., et al. Biosens. Bioelectron. 24, 2285-8, (2009)
Acetylcholinesterase Biosensor Design Based On Carbon Nanotube-encapsulated Polypyrrole And Polyaniline Copolymer For Amperometric Detection Of Organophosphates. Du, D., et al. Biosens. Bioelectron. 25, 2503-8, (2010)
Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect. Szegletes, T., et al. Biochemistry 38, 122-133, (1999)
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|H5777||(±)-Huperzine A, from synthetic, ≥98% (TLC)|
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