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C3412 Sigma

Cyproterone acetate

≥98%

Synonym: 6-Chloro-1β,2β-dihydro-17-hydroxy-3′H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate

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Properties

Related Categories Androgen Modulators, Antitumor Agents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   UWFYSQMTEOIJJG-FDTZYFLXSA-N
assay   ≥98%
storage temp.   2-8°C
Gene Information   human ... AR(367)
mouse ... Nr3c1(14815)
rat ... Ar(24208)

Description

Packaging

250 mg in poly bottle

Biochem/physiol Actions

Synthetic steroid; androgen antagonist; potent inhibitor of leukocyte migration through endothethial cell monolayers. Liver tumor promoter in experimental animal model. Liver tumor promotion appears to be female gender-specific, as formation of an active metabolite that forms DNA adducts.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C3412.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GZ2230000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

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Peer-Reviewed Papers
15

References

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