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C3460 Sigma

Casein Kinase II from rat liver

≥90% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: CK 2, CK II

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
assay   ≥90% (SDS-PAGE)
form   buffered aqueous glycerol solution
mol wt   α and α′ subunits mol wt 36-44 kDa
  β subunit mol wt 25 kDa
  tetramer mol wt 120-140 kDa (α2β2 or αα′β2)
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Csnk2a1(116549), Csnk2b(81650)

Description

Biochem/physiol Actions

CK II is a protein serine/threonine kinase that is ubiquitously distributed in eukaryotes. CK II is an important component of signaling pathways; controls the growth and division of cells and regulates the activity of a variety of regulatory nuclear proteins.
The activity of CK II is measured by in vitro phosphorylation of casein in the presence and in the absence of an inhibitor (heparin).

Unit Definition

One unit will transfer 1 nmole of phosphate from ATP to casein per min at 37 °C at pH 7.5.

Physical form

Solution in 40 mM HEPES, pH 7.5, 1 mM EDTA, 1 mM EGTA, 1 mM DTT, 0.4 M NaCl, and 50% glycerol

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles
Peer-Reviewed Papers
15

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