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C3535 Sigma

Complement C8 from human serum

suitable for radioiodination, RIA, ≥85% (SDS-PAGE), ≥125,000 C8H50 units/mg protein (using C8 deficient serum)

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Complement, Complement Factor Proteins,
assay   ≥85% (SDS-PAGE)
concentration   1 mg/mL in PBS, pH 7.2
suitability   suitable for radioiodination, RIA
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... C8A(731)

Description

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Quality

Functionally pure by a sensitive hemolytic assay using depleted sera.

Application

Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). In the (MAC), C8 initiates and coordinates MAC pore formation. It has been used in research to investigate the mechanisms of how C8-C9 and C9-C9 interactions facilitate folding of the membrane attack complex perforin (MACPF) domain to form the circular pore.

Biochem/physiol Actions

C8 is one of the components of the terminal complement complex and is required for a functional complement system. It is composed of disulfide-linked C8α and C8γ and a noncovalently associated C8β chain. During formation of the membrane-attack complex, a domain on C8α induces C9 to polymerize and form a pore-like structure.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Peer-Reviewed Papers
15

References

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