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C3662 Sigma

Cyclosporin A

from Tolypocladium inflatum, ≥95% (HPLC), solid

Synonym: Antibiotic S 7481F1, Cyclosporine

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
Quality Level   PREMIUM
biological source   from Tolypocladium inflatum
InChI Key   PMATZTZNYRCHOR-CGLBZJNRSA-N
assay   ≥95% (HPLC)
form   solid
color   white
solubility   dichloromethane: soluble10 mg/mL
  ethanol: soluble10 mg/mL
  DMSO: soluble50 mg/mL
  chloroform: soluble6 mg/mL
  H2O: insoluble
Mode of action   enzyme | inhibits
originator   Novartis
storage temp.   2-8°C
Gene Information   human ... PPP3CA(5530), PPP3CB(5532), PPP3CC(5533), PPP3R1(5534), PPP3R2(5535)

Description

Packaging

5, 10 mg in glass bottle

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GZ4120000
Protocols & Articles

Articles

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The immune system is a complex network to detect and defend against non-self pathogenic agents, such as disease-causing viruses, bacteria, and other microorganisms. Various signaling pathways contrib...
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Peer-Reviewed Papers
15

References

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