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C3735 Sigma

Cytochrome P450 human

1A1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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Description

Biochem/physiol Actions

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.

The CYP1A1 isoform catalyzes 7-deethylation of ethoxyresorufin.

Preparation Note

Microsomes containing human CYP1A1 and recombinant human NADPH-P450 reductase.

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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