Carbamazepine

Papers

Toxic Effects And Bioaccumulation Of Carbamazepine Evaluated By Biomarkers Measured In Organisms Of Different Trophic Levels. Vernouillet, G., et al. Chem. Biol. Interact. 80, 1062-8, (2010)

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Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design. Perumal Yogeeswari et al J. Med. Chem. 48, 6202-11, (2005)

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Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Yong-Hua Wang et al Bioorg. Med. Chem. Lett. 15, 4076-84, (2005)

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Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines. Zhi-Feng Xie et al Bioorg. Med. Chem. Lett. 15, 4803-5, (2005)

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UDP-glucuronosyltransferases and clinical drug-drug interactions. Tony K L Kiang et al Pharmacol. Ther. 106, 97-132, (2005)

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Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach. Perumal Yogeeswari et al J. Med. Chem. 50, 2459-67, (2007)

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High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery. Hong Wan et al J. Med. Chem. 50, 4606-15, (2007)

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Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain. Nadeem Siddiqui et al Bioorg. Med. Chem. Lett. 17, 255-9, (2007)

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Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails. Jean-Yves Winum et al Bioorg. Med. Chem. Lett. 17, 2685-91, (2007)

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Hologram QSAR model for the prediction of human oral bioavailability. Tiago L Moda et al Bioorg. Med. Chem. 15, 7738-45, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

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Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Johannes Kornhuber et al J. Med. Chem. 51, 219-37, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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Toward an optimal blood-brain barrier shuttle by synthesis and evaluation of peptide libraries. Morteza Malakoutikhah et al J. Med. Chem. 51, 4881-9, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Imidazopyridines: a novel class of hNav1.7 channel blockers. Clare London et al Bioorg. Med. Chem. Lett. 18, 1696-701, (2008)

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3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity. Scott B Hoyt et al Bioorg. Med. Chem. Lett. 18, 1963-6, (2008)

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Anticonvulsant activity of some xanthone derivatives. Henryk Marona et al Bioorg. Med. Chem. 16, 7234-44, (2008)

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N-{[(6-substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2/4-substituted benzamides: synthesis and pharmacological evaluation. Arpana Rana et al Eur. J. Med. Chem. 43, 1114-22, (2008)

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Synthesis of novel 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones as anticonvulsant agents. Zhong-Tai Piao et al Eur. J. Med. Chem. 43, 1216-21, (2008)

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Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones. Varsha Jatav et al Eur. J. Med. Chem. 43, 135-41, (2008)

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CNS depressant and anticonvulsant activities of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones. Varsha Jatav et al Eur. J. Med. Chem. 43, 1945-54, (2008)

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Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Anne Thiry et al Eur. J. Med. Chem. 43, 2853-60, (2008)

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Synthesis and anticonvulsant activity of some novel 3-aryl amino/amino-4-aryl-5-imino-Delta2-1,2,4-thiadiazoline. Arun Gupta et al Eur. J. Med. Chem. 43, 749-54, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Hong Wan et al J. Med. Chem. 52, 1693-700, (2009)

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Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. Felix M Rivas et al J. Med. Chem. 52, 1795-8, (2009)

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Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. Michael H Parker et al J. Med. Chem. 52, 7528-36, (2009)

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Synthesis and anticonvulsant activity of some substituted 1,2,4-thiadiazoles. Arun Gupta et al Eur. J. Med. Chem. 44, 1100-5, (2009)

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Design, synthesis of 8-alkoxy-5,6-dihydro-[1,2,4]triazino[4,3-a]quinolin-1-ones with anticonvulsant activity. Xian-Yu Sun et al Eur. J. Med. Chem. 44, 1265-70, (2009)

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Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants. Faizul Azam et al Eur. J. Med. Chem. 44, 203-11, (2009)

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Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors. Johannes Kornhuber et al Eur. J. Med. Chem. 44, 2667-72, (2009)

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Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Li-Ping Guan et al Eur. J. Med. Chem. 44, 3654-7, (2009)

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Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data. Elena Dreassi et al Eur. J. Med. Chem. 44, 3712-7, (2009)

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Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea. Sushil K Kashaw et al Eur. J. Med. Chem. 44, 4335-43, (2009)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Analgesic, anticonvulsant and anti-inflammatory activities of some synthesized benzodiazipine, triazolopyrimidine and bis-imide derivatives. Said A Said et al Eur. J. Med. Chem. 44, 4787-92, (2009)

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Design and synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. Li-Jun Guo et al Eur. J. Med. Chem. 44, 954-8, (2009)

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N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles. Morteza Malakoutikhah et al J. Med. Chem. 53, 2354-63, (2010)

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How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Alex Avdeef et al J. Med. Chem. 53, 3566-84, (2010)

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Novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles: one more step towards establishing four binding site pharmacophoric model hypothesis for anticonvulsant activity. Harish Rajak et al Bioorg. Med. Chem. Lett. 20, 4168-72, (2010)

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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

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Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Yun W Alelyunas et al Bioorg. Med. Chem. Lett. 20, 7312-6, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Synthesis and structure-activity relationships of antimalarial 4-oxo-3-carboxyl quinolones. Yiqun Zhang et al Bioorg. Med. Chem. 18, 2756-66, (2010)

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Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway. Mahindroo, N.; et al. Bioorg. Med. Chem. 18, 4801, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole. Nikhil D Amnerkar et al Eur. J. Med. Chem. 45, 149-59, (2010)

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Triazole incorporated thiazoles as a new class of anticonvulsants: design, synthesis and in vivo screening. Nadeem Siddiqui et al Eur. J. Med. Chem. 45, 1536-43, (2010)

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Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine. Li-Ping Guan et al Eur. J. Med. Chem. 45, 1746-52, (2010)

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Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides. Faizul Azam et al Eur. J. Med. Chem. 45, 2817-26, (2010)

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Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant activity. Xian-Qing Deng et al Eur. J. Med. Chem. 45, 3080-6, (2010)

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Design & synthesis of 2-(substituted aryloxy)-5-(substituted benzylidene)-3-phenyl-2,5-dihydro-1H-[1,2,4] triazin-6-one as potential anticonvulsant agents. Darpan Kaushik et al Eur. J. Med. Chem. 45, 3960-9, (2010)

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Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives. Xianran He et al Eur. J. Med. Chem. 45, 5870-7, (2010)

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SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Sam Hopkins et al Antimicrob. Agents Chemother. 54, 660-72, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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Synthesis and anticonvulsant activity of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2- or 4-hydroxycyclohexyl)acetamides and their amine analogs. Elżbieta Pękala et al Bioorg. Med. Chem. 19, 6927-34, (2011)

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Synthesis and anticonvulsant activity of 8-alkoxy-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1]benzazepin-1-one derivatives. Feng-Yu Piao et al Eur. J. Med. Chem. 46, 1050-5, (2011)

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Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. Xian-Qing Deng et al Eur. J. Med. Chem. 46, 2955-63, (2011)

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Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones. Perumal Yogeeswari et al Eur. J. Med. Chem. 46, 2964-70, (2011)

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Synthesis and anticonvulsant properties of new acetamide derivatives of phthalimide, and its saturated cyclohexane and norbornene analogs. Krzysztof Kamiński et al Eur. J. Med. Chem. 46, 4634-41, (2011)

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Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Nandita Sinha et al Eur. J. Med. Chem. 46, 618-30, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Design and synthesis of 3,5-diarylpiperidin-2,6-diones as anticonvulsant agents. Mariappan Babu et al Bioorg. Med. Chem. Lett. 22, 1263-6, (2012)

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Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones. Xianran He et al Eur. J. Med. Chem. 48, 338-46, (2012)

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Lamotrigine and carbamazepine affect differently the release of D-^3Haspartate from mouse cerebral cortex slices: involvement of NO. Afanas'ev, I. Neurochem. Res. 24, 1153, (1999)

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Valproate and carbamazepine increase prefrontal dopamine release by 5-HT_1A receptor activation. Ichikawa, J. Eur. J. Pharmacol. 380, R1-3, (1999)

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Merck 14,1781

Corp MSDS 1, 680:A / FT-IR 2 (2), 3066:D / FT-NMR 1 (2), 1451:A / RegBook 1 (2), 2073:E / Sax 6, 902 / Structure Index 1, 328:C:5