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C4116 Sigma

Cyclopamine hydrate

≥98% (HPLC)

Synonym: 11-deoxojervine hydrate

  • Empirical Formula (Hill Notation) C27H41NO2 · xH2O

  • Molecular Weight 411.62 (anhydrous basis)

  •  PubChem Substance ID 24724439

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Properties

Related Categories Angiogenic Factors, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
InChI Key   KDAGJRDPNXDDSB-HBYCUIHISA-N
assay   ≥98% (HPLC)
form   solid
color   white
solubility   DMSO: soluble ≥5 mg/mL
  H2O: insoluble
storage temp.   2-8°C
Gene Information   human ... EBP(10682)

Description

Biochem/physiol Actions

Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.

Packaging

1, 5 mg in glass bottle

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Price and Availability


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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Cancer Stem Cells: New Targets for Cancer Therapy

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Keywords: Cancer, Cell attachment, Cell culture, Cell proliferation, Gastrointestinal, Gene expression, Transcription, transformation

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during t...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Cell division, Cell proliferation, DNA replication, Diseases, Genetic

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Peer-Reviewed Papers
15

References

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