Coumarin

Papers

Quantitative structure-activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme. Minna Rahnasto et al J. Med. Chem. 48, 440-9, (2005)

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Synthesis and antiinflammatory activity of coumarin derivatives. Christos A Kontogiorgis et al J. Med. Chem. 48, 6400-8, (2005)

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Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. K W Ward et al Xenobiotica 35, 191-210, (2005)

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Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Larry J Jolivette et al J. Pharm. Pharm. Sci. 94, 1467-83, (2005)

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QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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Toward prediction of alkane/water partition coefficients. Anita Toulmin et al J. Med. Chem. 51, 3720-30, (2008)

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Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents. Kazuto Takaishi et al Bioorg. Med. Chem. Lett. 18, 5614-7, (2008)

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Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. Maria E Riveiro et al Bioorg. Med. Chem. 16, 2665-75, (2008)

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Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors. Theodoros Symeonidis et al Bioorg. Med. Chem. Lett. 19, 1139-42, (2009)

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Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors. Renato F Freitas et al Bioorg. Med. Chem. 17, 2476-82, (2009)

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Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells. María E Riveiro et al Bioorg. Med. Chem. 17, 6547-59, (2009)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. Alfonso Maresca et al J. Med. Chem. 53, 335-44, (2010)

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Synthetic human serum albumin Sudlow I binding site mimics. Björn C G Karlsson et al J. Med. Chem. 53, 7932-7, (2010)

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Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus. Satoru Tamura et al Bioorg. Med. Chem. Lett. 20, 3717-20, (2010)

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Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II. Alfonso Maresca et al Bioorg. Med. Chem. Lett. 20, 4511-4, (2010)

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6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Atsushi Kato et al Bioorg. Med. Chem. Lett. 20, 5630-3, (2010)

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7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. Alfonso Maresca et al Bioorg. Med. Chem. Lett. 20, 7255-8, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination. Changning Wang et al J. Med. Chem. 54, 2331-40, (2011)

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Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors. Nadia Touisni et al J. Med. Chem. 54, 8271-7, (2011)

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Synthesis and biological evaluation of (2,5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers. Anna Balabani et al Eur. J. Med. Chem. 46, 5894-901, (2011)

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Thymol, benzofuranoid, and phenylpropanoid derivatives: anti-inflammatory constituents from Eupatorium cannabinum. Jih-Jung Chen et al J. Nat. Prod. 74, 1021-7, (2011)

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New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II. Fabrizio Carta et al Bioorg. Med. Chem. Lett. 22, 2182-5, (2012)

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5- and 6-Membered (thio)lactones are prodrug type carbonic anhydrase inhibitors. Fabrizio Carta et al Bioorg. Med. Chem. Lett. 22, 267-70, (2012)

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Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII. Fabrizio Carta et al Bioorg. Med. Chem. 20, 2266-73, (2012)

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Structure-activity relationships for naturally occurring coumarins as ?-secretase inhibitor. Shinsuke Marumoto et al Bioorg. Med. Chem. 20, 784-8, (2012)

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Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities. Fylaktakidou KC, Hadjipavlou-Litina DJ, et al. Curr. Pharm. Des. 10, 3813-3833, (2004)

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Antiinflammatory and antioxidant evaluation of novel coumarin derivatives. Kontogiorgis CA, Savvoglou K, et al. J. Enzyme Inhib. Med. Chem. 21, 21-29, (2006)

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Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats. Murat Bilgin H, Atmaca M, et al. Exp. Toxicol. Pathol. 63, 325-330, (2011)

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Coumarin-conjugated multiwalled carbon nanotubes for potential biological applications: development and characterization. Lannazzo D, Piperno A, et al. J. Nanosci. Nanotechnol. 12, 5030-5038, (2012)

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[Antioxidant activity of hydroxy derivatives of coumarin].[Article in Russian] Potapovich MV, Metelitsa DI, Shadyro OI. Prikl. Biokhim. Mikrobiol. 48, 282-288, (2012)

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Merck 14,2562

Beil. 17,V,10,143

Aldrich MSDS 1, 490:C / Arctander, 704 / Corp MSDS 1 (1), 921:A / FT-IR 1 (2), 322:B / FT-IR 2 (2), 2906:B / FT-NMR 1 (2), 1311:B / Fenaroli, 131 / IR-Spectra (3), 1044:B / IR-Spectra (2), 913:B / NMR-Reference 2 (2), 309:A / RegBook 1 (2), 1943:A / Sax 6, 813 / Sigma FT-IR 1 (2), 117:D / Stains and Dyes Ref, 224 / Structure Index 1, 312:B:5 / Vapor Phase 3, 1386:C