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C4358 Sigma

CD152/Fc Chimera, Non-cytolytic from mouse

≥98% (SDS-PAGE), recombinant, expressed in NS.1 cells, lyophilized

Synonym: CTLA4/Fc Chimera, non-cytolytic

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Properties

Related Categories CD152/Fc Chimera, Cell Biology, Cell Signaling and Neuroscience, Cell Surface Molecules, Immune Cell Signaling and Blood,
recombinant   expressed in NS.1 cells
assay   ≥98% (SDS-PAGE)
form   lyophilized
mol wt   mol wt 97 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Ctla4(12477)

Description

Preparation Note

Purified from serum-free tissue culture supernatant

Physical form

Lyophilized from solution of 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.

Biochem/physiol Actions

CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.

General description

The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain in which mutations to the complement (C1q) and FcγR I binding sites of the Fcγ2a fragment render the Fc fusion protein incapable of direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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