|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Nucleoside Analogs,|
human ... NP(4860)|
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P280-P301 + P310-P305 + P351 + P338-P311|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||23/24/25-36/37/38|
|Safety Statements (Europe)||22-26-36-45|
Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions. Gandhi V, Estey E, Keating MJ, et al. Blood 87, 256-264, (1996)
Toward personalized therapy for chronic lymphocytic leukemia: DSC and cDNA microarray assessment of two cases. Rogalińska M, Franiak-Pietryga I, Błoński JZ, et al. Cancer Biol. Ther. 14(1), 6-12, (2013)
[Cladribine is highly effective in the treatment of Langerhans cell histiocytosis and rare histiocytic disorders of the juvenile xanthogranuloma group]. Adam Z, Szturz P, Pour L, et al. Vnitr. Lek. 58(6), 455-65, (2012)
Apoptotic gene expression under influence of fludarabine and cladribine in chronic lymphocytic leukemia-microarray study. Franiak-Pietryga I, Sałagacka A, Maciejewski H, et al. Pharmacol. Rep. 64(2), 412-20, (2012)
Topotecan exposure estimation in pediatric acute myeloid leukemia supported by LC-MS-based drug monitoring and pharmacokinetic analysis. Bączek T, Konieczna L, Belka M, et al. J. Pharm. Biomed. Anal. 70, 330-6, (2012)
Fludarabine and cladribine induce changes in surface proteins on human B-lymphoid cell lines involved with apoptosis, cell survival, and antitumor immunity. Kohnke PL, Mactier S, Almazi JG, et al. J. Proteome Res. 11(9), 4436-48, (2012)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?