|Related Categories||Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Nucleoside Analogs,|
human ... NP(4860)|
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P280-P301 + P310-P305 + P351 + P338-P311|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||23/24/25-36/37/38|
|Safety Statements (Europe)||22-26-36-45|
Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions. Gandhi V, Estey E, Keating MJ, et al. Blood 87, 256-264, (1996)
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