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C4438 Sigma

2-Chloro-2′-deoxyadenosine

antileukemic

DOWNLOAD MSDS (PDF)

Synonym: CdA, Cladribine

2-Chloro-2′-deoxyadenosine antileukemic
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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Nucleoside Analogs,
storage temp.   2-8°C
Gene Information   human ... NP(4860)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Description

Biochem/physiol Actions

Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity

Application

2-Chloro-2′-deoxyadenosine (2-CdA) is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).

Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias.

Price and Availability

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