• USA Home
  • C4461 - Colistin sulfate salt

EMAIL THIS PAGE TO A FRIEND

C4461 Sigma

Colistin sulfate salt

≥15,000 U/mg

Synonym: Polymyxin E

Description

Biochem/physiol Actions

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH 2.

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.

Application

Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii 1. It has been used to study hephrotoxicity in the rat kidney 2, and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa 3.

Price and Availability

Customers Also Viewed

Colistin sodium methanesulfonate

from Bacillus colistinus

Polymyxin B sulfate

meets USP testing specifications, powder

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?