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C4461 Sigma

Colistin sulfate salt

≥15,000 U/mg

Synonym: Polymyxin E

Description

Biochem/physiol Actions

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH 2.

Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.

Application

Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii 1. It has been used to study hephrotoxicity in the rat kidney 2, and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa 3.

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