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C4483 Sigma

CD152/Fc Chimera, Cytolytic from mouse

recombinant, expressed in NS.1 cells, buffered aqueous solution

Synonym: CTLA4/Fc Chimera, cytolytic

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Properties

Related Categories CD152/Fc Chimera, Cell Biology, Cell Signaling and Neuroscience, Cell Surface Molecules, Immune Cell Signaling and Blood,
recombinant   expressed in NS.1 cells
assay   ≥99% (SDS-PAGE)
form   buffered aqueous solution
mol wt   mol wt 97 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   mouse ... Cd152(12477), Ctla4(12477)

Description

Biochem/physiol Actions

CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.

General description

The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

Other Notes

The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.

Preparation Note

Purified from serum-free tissue culture supernatant

Physical form

Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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