|Related Categories||Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Cerosomes Control Microsomes, Cytochrome P450s (CYPs),|
|shipped in||dry ice|
For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.
Supplied as a solution containing 50 mM potassium phosphate, pH 7.4, 5% glycerol, 1 mM EDTA, 1 mM PMSF, and 2 mM DTT
Cytochrome P450 Microsome Preparation Human, product C4499, is a negative control without NADPH reductase and is produced in Saccharomyces cervisiae. Cytochrome P450 is used to catalyze the oxidative metabolism of xenobiotics and to study the biotransformation and elimination of drugs and pollutants from the body. Cytochrome P450 is used to study hormone synthesis and breakdown, cholesterol synthesis, drug metabolism and bioactivation and vitamin D metabolism1. Cytochrome P450 has been used as a negative control during the examination of CYP2S1 catalytic activity 2.
Microsomal cytochrome P450 enzymes are found primarily in the endoplasmic reticulum of liver tissue. They catalyze the oxidative metabolism of xenobiotics and are the major enzymes involved in drug metabolism and bioactivation1. The reactions are achieved through a mixed monooxygenase system. The cytochrome P450 enzymes range in molecular mass between 45-60 kDa.
Enzyme Nomenclature, (1992)
Guengrich, F.P. Cytochrome P450: Struct., Mech. & Biochem. 2ndth ed.,, (1995)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?