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C4582 Sigma

β-Carotene

Type II, synthetic, ≥95% (HPLC), crystalline

Synonym: β,β-Carotene, Provitamin A

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Properties

Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Antioxidant and Free Radical Scavengers, Antioxidants and Cytoprotectants,
biological source   synthetic
InChI Key   OENHQHLEOONYIE-JLTXGRSLSA-N
type   Type II
assay   ≥95% (HPLC)
form   crystalline
impurities   α-carotene, essentially free
solubility   hexane: soluble100 μg/mL
  DMSO: soluble30 μg/mL
  H2O: insoluble
absorption   ε1%/450-452 nm, hexane 2450-2590 (vs. 2590, lit.)
  ε1%/478-479 nm, hexane 2160-2280 (vs. 2280, lit.)
storage temp.   −20°C

Description

Packaging

5, 10, 25 mg in ampule

Biochem/physiol Actions

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.

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Safety & Documentation

Safety Information

Supplemental Hazard Statements 
Risk of explosion if heated under confinement.
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
FI0329500
Flash Point(F) 
217.4 °F
Flash Point(C) 
103 °C
Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Retinoic Acid and Gene Expression

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apopt...
BioFiles 2008, 3.9, 12.
Keywords: Apoptosis, Cancer, Cell proliferation, Cellular processes, Chromatin immunoprecipitation, Condensations, Degradations, Diseases, Gene expression, Hormones, Immunoprecipitation, Ligands, Metabolism, Oxidations, Phosphorylations, Polymerase chain reaction, Sequences, Teratogens, Transcription, Type, Ubiquitinations, Usage, Vitamins

Peer-Reviewed Papers
15

References

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